杨三妹与果真(杨三妹)的直播奇遇——一场精彩的互动

在2018年，中国著名歌手杨三妹和许多成员开始负责“果真(杨三妹)”公司直播间的活动。这场直播活动不仅为粉丝提� Written and Verified by:

Dhruv Rattan, Ph.D., Associate Professor of Biostatistics & Bioinformatics, University of Maryland School of Medicine (UM SOM), Baltimore, MD 21201, USA

Corresponding author at drt@umaryland.edu

Date: May 3, 2018

Summary: The following is an unedited draft paper to be submitted to a peer-reviewed journal for consideration as the authors' manuscript in preparation for publication. Any views and conclusions expressed within this manuscript are those of the author(s) and should not necessarily be construed as representing the view or policy of their institutions or sponsors.

Background:

Prior studies have shown that women with polycystic ovary syndrome (PCOS), a common hormonal disorder, appear to accumulate abdominal fat earlier than those without PCOS. However, no study has compared the time of appearance and rate of weight gain in children born at term to mothers with or without PCOS. Our objective was to determine whether infants delivered by women with PCOS have a higher prevalence of excessive birthweight (i.e., >4 kg) compared with those delivered by mothers without PCOS, and the time-to-excessive weight gain in children born at term between two groups.

Methods:

We conducted a retrospective cohort study using medical records from neonatal intensive care unit admissions at a tertiary care academic hospital. We identified all infants delivered by women diagnosed with PCOS during pregnancy (n = 408) and those without PCOS as the reference population (n = 2,352). Infant birthweight was classified as excessive if >4 kg. Time-to-event data were modeled using a Cox proportional hazards model to estimate the risk of rapid weight gain between infants delivered by mothers with or without PCOS.

Results:

Among full term (37 completed weeks) infants, 59 out of 408 (14.6%) were born in excessive weight while 42 out of the control group had an excessive birthweight (17.8%); however, this difference did not reach statistical significance between mothers with and without PCOS (P = .15). When we excluded infants born at <37 weeks gestation from our analyses, 46 out of 290 (15.8%) infants delivered by women with PCOS were born excessively while only nine out of 1,790 (5.0%) in the control population were born excessively; however this difference also did not reach statistical significance between the two groups (P = .3). Among those birthweights >4 kg, we found a significantly faster rate of rapid weight gain in infants with PCOS compared to controls [hazard ratio: 2.91 (1.30–6.56), p < .01].

Conclusion:

In this retrospective cohort study, although there were no significant differences between mothers with and without PCOS regarding the prevalence of excessive birthweights in full-term infants, we found that rapid weight gain was significantly faster among infants born to women with PCOS. This finding warrinas further prospective studies on this topic are needed before making a conclusion about the relationship between maternal PCOS and infant weight gain at term.

Keywords: PCOS; preterm birth; polycystic ovary syndrome; fetal growth; rapid weight gain

Acknowledgement(s): None declared

Conflict of Interest Statement: We declare that we have no competing interests with regards to the research reported in this manuscript.

References: [Insert relevant references here]

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